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2 edition of Oxygen free radicals, Immunoglobulin G and rheumatoid arthritis found in the catalog.

Oxygen free radicals, Immunoglobulin G and rheumatoid arthritis

Helen Rosemary Griffiths

Oxygen free radicals, Immunoglobulin G and rheumatoid arthritis

by Helen Rosemary Griffiths

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Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D)-University of Birmingham, Depr of Medinice, 1989.

Statementby Helen Rosemary Griffiths.
ID Numbers
Open LibraryOL13891327M

The role of free radicals in the pathogenesis of rheumatoid arthritis. ROS, produced by activated phagocytes, could alter the antigenic behaviour of immunoglobulin G, producing fluorescent protein aggregates that can further activate phagocytic cells. Radical-exposed IgG is able to bind rheumatoid factor and results in the generation of. ISBN: OCLC Number: Description: xi, pages: illustrations: Contents: Free radicals and human disease - trick or treat?; oxygen free radical involvement in cerebral ischemia/reperfusion injury; oxygen radicals and ageing; free radicals in rheumatoid arthritis - redox regulation of gene transcription and .

  Alteration of IgG by oxygen-derived free radicals has been implicated in an in vivo process which renders IgG autoantigenic and leads to the production of rheumatoid factor (RF) and the perpetuation of inflammation, as in rheumatoid arthritis (RA). In this study the impact of UV irradiation on IgG was investigated as well as the ability of RF to bind to UV-altered Cited by: Activated B cells produce plasma cells, which form antibodies that, in combination with the complement system, result in accumulation of polymorphonuclear leukocytes. These leukocytes release cytotoxins, oxygen-free radicals, and hydroxyl radicals that promote damage to synovium and bone.

The generations of oxygen free radicals from metabolism of oxygen and an increase in reactive oxygen species (ROS) have been reported to have important roles in the pathogenesis of . ISBN: OCLC Number: Description: xi, pages: illustrations ; 26 cm: Contents: Free radicals and human disease - trick or treat?; oxygen free radical involvement in cerebral ischemia/reperfusion injury; oxygen radicals and ageing; free radicals in rheumatoid arthritis - redox regulation of gene transcription and proteolytic tissue .


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Oxygen free radicals, Immunoglobulin G and rheumatoid arthritis by Helen Rosemary Griffiths Download PDF EPUB FB2

The nature of oxygen free radicals Sources of oxygen free radicals Interaction between iron and oxygen free radicals Biological effects Protectors Oxygen free Immunoglobulin G and rheumatoid arthritis book in ischemia 7 9 10 16 Evidence for a role of oxygen free radicals in the patho- 23 genesis of rheumatoid arthritis Sources of oxygen free radicals in rheumatoid arthri­ tisCited by: 1.

The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as rheumatoid arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked.

The widespread involvement of radicals in human disease. The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as Immunoglobulin G and rheumatoid arthritis book arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked.

Oxygen free radicals are probably involved in the pathogenesis of rheumatoid arthritis (RA). The enzymes involved in protection against oxygen free radicals.

Background Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Highly reactive oxygen free radicals are believed to be involved in the pathogenesis of the disease. In this study, RA patients were sub-grouped depending upon the presence or absence of rheumatoid factor, disease activity score and disease duration.

RA Patients () and healthy controls (53) Cited by:   Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Highly reactive oxygen free radicals are believed to be involved in the pathogenesis of the disease.

In this study, RA patients were sub-grouped depending upon the presence or absence of rheumatoid factor, disease activity score and disease by: Oxygen Free Radicals and Human Diseases Article Literature Review (PDF Available) in Journal of the Royal Society of Health (5).

Some common free radicals are such as superoxide anion radical (O 2 •−), hydroxyl radical, (•OH), Peroxyl radical (HOO•),Nitric oxide (NO•) etc.

The present paper concentrates on the reviewing of the evidences concerning the involvement of free radicals in Rheumatoid Arthritis and their relationship to specific pathophysiological events. Background: Oxygen free radicals have been implicated as mediators of tissue damage in patients of rheumatoid arthritis (RA).This study was designed to elucidate plasma oxidant/antioxidant status in rheumatoid arthritis, with the aim of evaluating the importance of antioxidant therapy in the management of this by: Inflammatory sites are characterised by the presence of large numbers of phagocytes, which release a variety of glycolytic enzymes [10] and oxygen free radicals (OFRs) [11].

Previous studies from this group have shown that OFRs can induce a new visible fluorescence in IgG indistinguishable from that found in rheumatoid IgG [4].Cited by: Topics covered include Alzheimer's disease, cerebral ischemia, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, ARDS, critical care medicine and cancer.

This book not only provides an invaluable resource for those seeking up to date information on the evidence supporting the involvement of oxygen radicals in human disease, but Cited by: Biemond P, Swaak AJ, Koster JF.

Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid. Arthritis Rheum. Jul; 27 (7)– Gutteridge JM, Rowley DA, Griffiths E, Halliwell B.

Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic by: The culprits are increased inflammation, increased oxygen free radicals causing our joints to "rust" from chronically elevated blood sugar levels, and hormonal imbalance.*Dietary strategies to decrease the production of oxygen free radicals and to turn off genes that lead to cartilage breakdown.*Joint nutrients that can combat osteoarthritis /5(20).

Indian Journal of Rheumatology March Original Article Volume 3, Number 1; pp. 8–12 Free radical and antioxidant status in rheumatoid arthritis K Bhowmick 1, G Chakraborti 3, NS Gudi 2, AV Kutty Moideen 1, HV Shetty 1 ABSTRACT Introduction: Rheumatoid arthritis (RA) has long been categorized as a connective tissue disease and an autoimmune disease, but was Cited by: 9.

Cao W, Carney JM, Duchon A, Floyd RA, Chevion M. Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci Lett. May 26; 88 (2)– Canavese C, Stratta P, Vercellone A. The case for oxygen free radicals in the pathogenesis of ischemic acute renal failure.

Nephron. ; 49 (1):9–Cited by: Abstract. Immunoglobulin G (IgG) is a major serum glycoprotein, induced by the presence of foreign proteins. However, in rheumatoid arthritis, it is believed to be chemically altered so that IgG itself is no longer recognised as “self,” and an immune response is generated to this apparently foreign protein.

1 This is thought to promote the chronicity of the by: 2. In the sera and synovial fluid of patients with rheumatoid arthritis, part of the IgG fraction is found in an aggregated and fluorescent form. Oxygen-free radicals have been implicated in this denaturation, although the precise radical species responsible is by: In inflammatory arthritis, there is evidence indicating that the affected tissues produce large amounts of oxygen-free radicals and NO.

Herein, we examine the. Lunec J, Halloran SP, White AG, Dormandy TL. Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis.

J Rheumatol. Mar-Apr; 8 (2)– Rosen GM, Rauckman EJ. Spin trapping of superoxide and hydroxyl radicals. Methods Enzymol. ; –Cited by: Nuclear factor-kß (NF-kß) has been implicated in AIDS, as HIV is NF-kß dependent.

In the case of rheumatoid arthritis, rheumatoid factor binds IgG when it is exposed to free radicals. This binding stimulates the production of more free radicals, which then attack the. To determine the effect of tocilizumab (TCZ) on reactive oxygen species (ROS) in 11 patients with rheumatoid arthritis (RA), reactive oxygen metabolites (d-ROM) were measured using a Free Radical Elective Evaluator.

The Disease Activity Score (DAS28) and matrix metalloproteinase-3 (MMP-3) level were also evaluated. d-ROM measured ± Author: Naoki Kondo, Katsumitsu Arai, Takahiro Netsu, Tomotake Kanai, Hiroshige Sano, Go Okumura, Yasufumi K.Free radicals and other reactive oxygen species are constantly formed in the human body and have been implicated in human diseases such as cancer, atherosclerosis, rheumatoid arthritis, Parkinson's disease, and malaria.

This observation has raised the possibility that antioxidants could act as prophylactic agents. However, it remains to be fully established whether oxidative 5/5(1).Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation.

J Clin Invest. Dec; 76 (6)– [PMC free article] Eggleton P, Wang L, Penhallow J, Crawford N, Brown KA. Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid by: